Akkermansia Muciniphila Probiotic Granules * Live Long * Weight Control Dogadan Bizim (5)

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One key characteristic of Akkermansia muciniphila​ is its capacity to live in the mucus and use it. It expresses a large panel of specific mucus-degrading enzymes and so it does not rely on dietary substances to feed itself. This ability provides Akkermansia muciniphila ​with a competitive advantage compared to other bacteria that do rely on fibres and other food particles as their main nutrient source.

Anhe FF, Jensen BAH, Perazza LR, Tchernof A, Schertzer JD, Marette A. Bacterial postbiotics as promising tools to mitigate cardiometabolic diseases. J Lipid Atheroscler. 2021;10:123–9. Rosadini CV, Kagan JC. Early innate immune responses to bacterial LPS. Curr Opin Immunol. 2017;44:14–9. All the effects on the mucin layer by Akkermansia muciniphila are exciting, but what makes researchers excited are its effects on diabetes and obesity. Initial research is telling us that it benefits us mostly through its ability to consume and produce mucus, strengthening the walls of our intestines

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The ‘muciniphila’ part comes from Akkermansia’s love of mucus. That’s right, it loves to eat the slimy layer of mucus that coats our intestinal walls. It keeps us healthy at the same time, so that’s a good thing. Recently, Akkermansia has been getting a lot of attention because several studies have linked it to leanness, as well as a resistance to obesity and type 2 diabetes.

Verhoog S, Taneri PE, Diaz ZMR, Marques-Vidal P, Troup JP, Bally L, Franco OH, Glisic M, Muka T. Dietary factors and modulation of bacteria strains of Akkermansia muciniphila and Faecalibacterium prausnitzii: a systematic review. Nutrients. 2019;11:1565. Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen J, Tsai PC, et al. DNA Methylation analysis identifies loci for blood pressure regulation. Am J Hum Genet. 2017;101:888–902. For a bigger picture on how raising your Akkermansia level could improve your health, talk to a Functional Medicine Practitioner or Registered Nutritional Therapist Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Carvajal JM, Zadeh M, Gong M, Qi Y, Zubcevic J, et al. Gut dysbiosis is linked to hypertension. Hypertension. 2015;65:1331–40. Jian H, Liu Y, Wang X, et al. Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut-Liver-Brain Axes? Int J Mol Sci. 2023 Feb 15;24(4):3900.But this isn’t entirely bad news. Research shows that in the quest for gut health, prebiotics are just as powerful as probiotics. While probiotics are live beneficial bacteria, prebiotics are the fertiliser for the bacteria you currently have. And as it appears that most of us already carry Akkermansia, it could be that all we need to do is feed them properly. The bacteria can restore intestinal barrier function, which can reduce inflammation and eventually help manage the storage of fat, energy expenditure and glucose metabolism. Stijn Oste, CEO of Metagenics Europe , ​says: “We are very proud to be the first company to sign a partnership agreement with The Akkermansia Company.​ Dan X, Mushi Z, Baili W, Han L, Enqi W, Huanhu Z, Shuchun L. Differential analysis of hypertension-associated intestinal microbiota. Int J Med Sci. 2019;16:872–81. So in addition to polyphenols and fish oil, make sure you add prebiotic foods to your daily menu. Many of them also contain polyphenols, so your Akkermansia can get a double hit of goodness. For instance:

Thomaz FS, Altemani F, Panchal SK, Worrall S, Dekker Nitert M. The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats. J Hum Hypertens 2021, 35:170-80.So, activation of the LPS pathway might be detrimental in inciting hypertension through various mechanisms, such as endothelial dysfunction through the release of inducible nitric oxide, activating TLR4, and vasculature inflammation through the release of NADPH oxidase-dependent free radicals [ 87– 89]. On the other hand, Akkermansia supplementation reduced low-grade inflammation by suppressing circulatory LPS in HFD-diet mice [ 64]. Trimethylamine-N-oxide Chen M, Hou P, Zhou M, Ren Q, Wang X, Huang L, Hui S, Yi L, Mi M. Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system. Clin Nutr. 2020;39:1264–75. Zhou T, Chien MS, Kaleem S, Matsunami H. Single cell transcriptome analysis of mouse carotid body glomus cells. J Physiol. 2016;594:4225–51. The bacteria was first discovered, isolated and characterised from the human gut microbiota in 2004, in the laboratory of Prof. Willem M de Vos (Wageningen University, The Netherlands), a co-founder of A-Mansia. Ozemek C, Laddu DR, Arena R, Lavie CJ. The role of diet for prevention and management of hypertension. Curr Opin Cardiol. 2018;33:388–93.

Luo Y, Zhang Y, Han X, Yuan Y, Zhou Y, Gao Y, Yu H, Zhang J, Shi Y, Duan Y, et al. Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis. EBioMedicine. 2022;82:104087. Nunez-Cordoba JM, Valencia-Serrano F, Toledo E, Alonso A, Martinez-Gonzalez MA. The Mediterranean diet and incidence of hypertension: the Seguimiento Universidad de Navarra (SUN) study. Am J Epidemiol. 2009;169:339–46. Shin NR, Lee JC, Lee HY, Kim MS, Whon TW, Lee MS, Bae JW. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut. 2014;63:727–35. Zhao S, Liu W, Wang J, Shi J, Sun Y, Wang W, Ning G, Liu R, Hong J. Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice. J Mol Endocrinol. 2017;58:1–14. Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, et al. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome. 2017;5:14.

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Akkermansia muciniphila is a type of bacteria found in your gut. Lately, it’s been getting a lot of press for its association with leanness and general health. Leeming ER, Johnson AJ, Spector TD, Le Roy CI. Effect of diet on the gut microbiota: rethinking intervention duration. Nutrients. 2019;11:2862. Rodrigues VF, Elias-Oliveira J, Pereira ÍS, et al. Akkermansia muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes. Front Immunol. 2022 Jul 7;13:934695. Ding RX, Goh WR, Wu RN, Yue XQ, Luo X, Khine WWT, Wu JR, Lee YK. Revisit gut microbiota and its impact on human health and disease. J Food Drug Anal. 2019;27:623–31.